Bioinformatics Learning Resources

NCBI Educational Page: http://www.ncbi.nlm.nih.gov/education/
The National Center for Biotechnology Information is a major source of gene-based information including genome and gene sequence, variation and function, and protein sequence, structure and function, as well as PubMed. The Education Page can help you to use these databases and tools effectively.

  • Getting Started: How-to Guides  http://www.ncbi.nlm.nih.gov/guide/all/#howtos  for directions on using NCBI tools to answer questions such as finding the function of a gene, finding human variation associated with a phenotype or disease, or viewing the SNPs of a gene.
  • NCBI Videos on YouTube  http://www.youtube.com/NCBINLM
    for tutorials on using NCBI resources, Gene Expression, Analyzing data, using Genome Workbench, NCBI's tool for viewing and analyzing sequence data.

Cold Spring Harbor Dolan DNA Learning Center   http://www.dnalc.org/
3D Animation library  http://www.dnalc.org/resources/3d/index.html  includes DNA packaging, replication, transcription, translation, RNA splicing, cell signaling and how various techniques (recombination, PCR, microarray and sequencing work.

EMBL-EBI  http://www.ebi.ac.uk/
The European Molecular Biology Laborator-European Bioinformatics Institute has many tools that address the entire range of bioinformatics analyses from genes and genomics, gene expression, pathways, proteins and proteomics and small molecules. The training pages have links to workshops as well as on-line training. Training tutorials and video workshops can be filtered by topic, level and duration.

Ensembl:  www.ensembl.org/

  • The Ensembl Project, a joint effort the EMBL-EBI and Sanger Centre, does automatic annotation of genomes and integrates other data (phenotype, variation, regulation) and provides a browser to view that data in the context of the genome. Ensembl has genomes for many organisms and powerful tools for viewing data (including your own) and mining and downloading data.

UCSC Genome Browser: http://genome.ucsc.edu/
UCSC provides access to annotations of epigenetic regulation from ENCODE, the Encyclopedia of DNA Elements that influence gene expression. The UCSC Genome Browser allows one to view the genome with tracks showing expression of these elements, such as histone modification, DNA methylation, and DNAse hypersensitivity, in a variety of different tissues. By zooming the view down the elements can be viewed at the sequence level.

  • The sequence of the Neandertal genome is available and can be viewed in comparison to the human genome.
  • The UCSC Genome Browser Help tab has information on how to use the browser. Additional training and help can be found at https://genome.ucsc.edu/training.html
  • In addition, Open Helix has tutorials on use of UCSC Genome Browser:  http://www.openhelix.com/cgi/freeTutorials.cgi